Nemo-Like Kinase Regulates Postnatal Skeletal Homeostasis
نویسندگان
چکیده
منابع مشابه
Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development.
The development of anterior neural structure in Xenopus laevis requires the inhibition of bone morphogenic protein 4 and Wnt signaling. We previously reported that Nemo-like kinase (NLK) negatively regulates Wnt signaling via the phosphorylation of T-cell factor/lymphoid enhancer factor. However, the molecular events occurring downstream of NLK pathways in early neural development remain unclea...
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The canonical Wnt signaling can be silenced either through β-catenin-mediated ubiquitination and degradation or through phosphorylation of Tcf and Lef by nemo-like kinase (NLK). In the present study, we generated NLK deficient animals and found that these mice become cyanotic shortly before death because of lung maturation defects. NLK-/- lungs exhibited smaller and compressed alveoli and the m...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2014
ISSN: 0021-9541
DOI: 10.1002/jcp.24625